Severe condition of Scrub Typhus Meningo- encephalitis in a child: a case report from Delhi, India

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Richa Malik
Shobha Sharma
Ratan Gupta
Rachna Sehgal

Abstract

Intracellular parasites are the causative organism of Rickettsial diseases which are pathophysiologically associated with vascular endothelium and reticuloendothelial cells. Scrub typhus is one of the rickettsial infections, where fever is a common symptom. Apart from this, non specific constitutional symptoms and sometimes organ based deterioration including CNS has also been observed. There are reports of scrub typhus with CNS complication like meningoencephalitis in adolescent and adults from various parts of India but not from Delhi. Recently few cases of scrub typhus in adults were reported from Delhi without involvement of CNS. Its occurrence as severe case of hemorrhagic fever with meningo-encephalitis is rarer in children and not so far reported from state of Delhi. We present a case of 4 year old female child from Delhi presenting with scrub typhus meningo-encephalitis, whose timely diagnosis and management saved her life and make us notice the emergence of meningoencephalitic like picture in children in Delhi.

Article Details

How to Cite
Malik, R., Sharma, S., Gupta, R., & Sehgal, R. (2014). Severe condition of Scrub Typhus Meningo- encephalitis in a child: a case report from Delhi, India. Medical Science, 2(3), 126-129. https://doi.org/10.29387/ms.2014.2.3.126-129
Section
Case Reports
Author Biographies

Richa Malik, VMMC & Safdarjung Hospital, New Delhi, India

MBBS, Senior Resident, Department of Pediatrics

Shobha Sharma, VMMC & Safdarjung Hospital, New Delhi

MD, Associate Professor, Department of Pediatrics

Ratan Gupta, VMMC & Safdarjung Hospital, New Delhi, India

MD - Senior Specialist, Department of Pediatrics

Rachna Sehgal, VMMC & Safdarjung Hospital, New Delhi, India

MD, Assistant Professor, Department of Pediatrics

References

Sahni SK, Rydkina E. Host-cell interactions with pathogenic Rickettsia species. Future Microbiol. 2009;4(3):323-39.

Sirisanthana V, Puthanakit T, Sirisanthana T. Epidemiologic, clinical and laboratory features of scrub typhus in thirty Thai children. Pediatr Infect Dis J. 2003;22(4):341-5.

Silpapojakul K. Scrub typhus in the Western Pacific region. Ann Acad Med Singapore. 1997;26(6):794-800.

Premaratna R, Chandrasena TG, Dassayake AS, Loftis AD, Dasch GA, de Silva HJ. Acute hearing loss due to scrub typhus: a forgotten complication of a reemerging disease. Clin Infect Dis. 2006 Jan 1;42(1):e6-8.

Saifudheen K, Kumar SKG, Jose J, Veena V, Gafoor VA. First case of scrub typhus with meningoencephalitis from Kerala: An emerging infectious threat. Ann Indian Acad Neurol. 2012; 15(2): 141–144.

Berman SJ, Kundin WD. Scrub typhus in South Vietnam. A study of 87 cases. Ann Intern Med. 1973;79(1):26-30.

Mahajan SK1, Rolain JM, Kashyap R, Bakshi D, Sharma V, Prasher BS, Pal LS, Raoult D. Scrub typhus in Himalayas. Emerg Infect Dis. 2006;12(10):1590-2.

Mahajan SK, Kashyap R, Kanga A, Sharma V, Prasher BS, Pal LS. Relevance of Weil-Felix test in diagnosis of scrub typhus in India. J Assoc Physicians India. 2006;54:619–21.

Chaudhry D, Garg A, Singh I, Tandon C, Saini R. Rickettsial diseases in Haryana: not an uncommon entity. J Assoc Physicians India. 2009;57:334–7.

Mathai E, Rolain JM, Verghese GM, Abraham OC, Mathai D, Mathai M. Outbreak of scrub typhus in southern India during the cooler months. Ann N Y Acad Sci. 2003;990:359–64.

Drevets DA, Leenen PJM, Greenfield RA. Invasion of central nervous system by intracellular bacteria. Clin Microbiol Rev. 2004;17(2):323–47.

Mahajan SK, Rolain JM, Kanga A, Raoult D. Scrub Typhus Involving Central Nervous System.Emerg Inf Disease J.2010;16(10):1641-43

Digra SK, Saini GS, Singh V, Sharma SD,Kaul R. Scrub Typhus in Children: Jammu Experience. 12(2):95-97. URL: http://www.jkscience.org/archive/volume122/Scrub%20Typhus%20in%20Children_Jammu%20Experience17.pdf

Moron, C. G., V. L. Popov, H. M. Feng, D. Wear, and D. H. Walker. 2001. Identification of the target cells of Orientia tsutsugamushi in human cases of scrub typhus. Mod. Pathol. 14(8):752–759.

MVS Subhalaxmi, Naval Chandra, Ved Teja et al. Scrub typhus-experience from a South Indian tertiary care hospital. BMC Infectious Diseases 2012, 12(Suppl 1):77

Prakash A, Acharya AS, Jain N, Bhattacharya D, Chhabra M. Scrub typhus- an emerging public health problem in Delhi. IJMS DOI-http://dx.doi.org/10.7713/ijms.2013.0044

Silpapojakul K, Ukkachoke C, Krisanapan S, Silpapojakul K. Rickettsial meningitis and encephalitis. Arch Intern Med. 1991 Sep; 151(9):1753-7.

Kim DE, Lee SH, Park KI, Chang KH, Roh JK. Scrub typhus encephalomyelitis with prominent focal neurologic signs. Arch Neurol. 2000 Dec; 57(12):1770-2.

Yang SH, Wang LS, Liang CC, Ho YH, Chang ET, Cheng CH. Scrub typhus complicated by intracranial hemorrhage - A Case report. Tzu Chi Med J. 2005;17:111–14.

Digra SK, Saini GS, Singh V, Sharma SD,Kaul R. Scrub Typhus in Children: Jammu Experience. www.jkscience.org.2012;12(2):95-97.

Pai H, Sohn S, Seong Y, Keem S, Chang, WH, Choe KW. Central Nervous System Involvement in Patients with Scrub Typhus. Clinical Infectious Diseases 1997; 24(3):436-40.

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