Neuroimmunomodulatory responses in brain inflammation
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Abstract
The human body is protected against different infections by identifying and killing the pathogens and tumor cells which attacks and alters the functions of the healthy cells and organs; this is referred to as the human body’s immune system. This system can be described as a homeostatic mechanism as this maintains the constancy and integrity of body cells and tissues under physiological conditions. Research established a connection in between the central nervous system (CNS) and the immune system where the former is known to interact with the later via a complex set of network that includes different neural, hormonal and paracrine actions which can emit and receive bi-directional signals. Stimulation of the immune system by any foreign pathogens produces a series of responses like alteration in the activity of neuroendocrine axis, fever, anorexia, inactivity and changes in the sleep-awake cycle in the CNS. These responses are mediated by the hypothalamus; this is referred to as Neuroimmunomodulation
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Sirisinha S. Insight into the mechanisms regulating immune homeostasis in health and disease. Asian Pac J Allergy Immunol. 2011; 29(1):1-14.
Davies TF, Larsen PR. Thyrotoxicosis. In: Williams Textbook of Endocrinology, 10th edition, Philadelphia: Saunders, 2003,pp 374–421.
Barone FC, Kilgore KS. Role of inflammation and cellular stress in brain injury and central nervous system diseases. Clinical Neuroscience Research. 2006; 6(5):329-56.
De la Fuente M. Role of neuroimmunomodulation in aging. Neuroimmunomodulation 2008; 15(4-6):213-23.
Vezzani A, Granata T. Brain Inflammation in Epilepsy: Experimental and Clinical Evidence. Epilepsia, 2005; 46(11): 1724-43.
Perlstein RS, Whitnall MH, Abrams JS, Mougey EH, Neta R. Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo. Endocrinology. 1993;132(3):946-52.
Baumann H, Gauldie J. The acute phase response. Immunol Today.1994;15(2):74–80.
Reichlin S. Neuroendocrine-immune interactions. N Engl J Med.1993;329:1246–53.