Evaluation of cardio metabolic profile, endothelial dysfunction and oxidative stress in metabolic Syndrome: a comparative perspective

Abstract

Background

In metabolic syndrome, endothelial cells are directly exposed to reactive oxygen species and increase the risk of various complications. Therefore, the objective of the present study was to evaluate the markers of oxidative stress (malondialdehye, ceruloplasmin and uric acid), endothelial dysfunction (nitric oxide) and serum magnesium levels along with the variation in waist circumference, lipid and glycemic profile among the metabolic syndrome patients and to compare it with that of healthy controls.

Methods

The parameters were estimated using standard methods in 50 healthy control group and 50 patients with metabolic syndrome. The obtained values were compared statistically by using paired t –test.  

Results

It was observed that the serum nitric oxide and magnesium levels were significantly reduced (p<0.01) whereas serum malondialdehyde levels were increased (p<0.001) along with significant rise in serum uric acid (p<0.01) and ceruloplasmin levels (p<0.01) in metabolic syndrome patients.

Conclusion

These findings support that there are noticeable alterations in the level of markers of oxidative stress and components of metabolic syndrome which collectively impair the endothelial function and thereby enhances the risk of future cardiovascular complications.